Parkinson’s disease symptoms and Salicylic acid
A new study used a compound in aspirin Alzheimer’s, Parkinson’s, and Huntington’s diseases, a range of neurodegenerative diseases, including the cumulative prevent cell death that binds to the enzyme GAPDH is discovered.
Salicylic acid – – such as arthritis, lupus, sepsis, and a range of different types of cancer as a disease that is associated with the gene coding for a protein called HMGB1 target the same team showed that the multi aspirin component news comes just months. In other words, the world’s most difficult task now painkiller ill effects of inflammation and oxidative stress that the new treatment offers the potential for all the way of salicylic acid which is derivatives to more powerful synthetic derivatives of natural search coupled with GAPDH and regulate the activities of HMGB1 and a better understanding of how salicylic acid, salicylic acid-based treatment for the development of new and improved offers great promise destructive, a wide variety of common diseases, said by the Daniel Klessig researcher from Cornell University
GAPDH (glyceraldehyde 3-phosphate dehydrogenase) to regulate how the body metabolises glucose is genetically DNA responsible, but Klessig and his team also have a number of different roles within the cell appears to play that discovery. The primary breakdown product of aspirin – – Klessig salicylic acid has spent years looking at how the immune system controls in plants, but people would answer, to see a bunch of human proteins decided to test it out.
The researchers found that neurons in the brain experienced oxidative stress – reactive oxygen species (free radicals) and the balance between the productions of antioxidant protection is thrown out of whack when – GAPDH move the business to increase protein in the nucleus, and it leads to cell death.
They tested the effect of salicylic acid on GAPDH, when the two were bound together but, as they have seen. GAPDH mean it is no longer in the nuclei of brain neurons could pass. “Long thought to work perfectly in glucose metabolism enzyme GAPDH, now called to strive in intracellular communicating,” one of the team, Solomon Snyder of Johns Hopkins University said. “The new study GAPDH could be relevant to the functions of such therapeutic drugs related to aspirin because salicylate is a target for drugs, and establishes that.”
The team is now the option of a comprehensive treatment capacity of salicylic acid as their investigation continues. They say they’re going to focus future research efforts is where the liquorices plant is a variety of Chinese and a synthetic version can be extracted from both the salicylic acid derivative, compared to a net version GAPDH more firmly bound to appear.