Skincare solutions are only as good as their components. In fact, moisturizers or for that matter any skin-care solution declaring to have an action on SKIN REPAIRshould contain a mixture of antioxidants, cell-communicating elements, and intercellular substances. These agents are responsible for aiding the skin to maintain a healthy level of hydration while producing collagen and avoiding cellular damage.
Most products incorporate harmful ingredients instead of using natural ingredients. Examples of some organic skin care ingredients are: rose hip oil, squalene and other olive oil by-products, and hyaluronic acid, a glycosaminoglycan found in the intercellular matrix of the skin where it has a defensive preserving structure and shock-minimizing role. It also plays a crucial role in tissue hydration, lubrication and cellular activity, and is capable of holding more water than any other biological substance.
Glycosaminoglycans – Permanent Controllers of Cellular Activities
These celullar elements collaborate in cell-matrix interactions and play a crucial natural role in fibroblasts production, specialization and migration by efficiently adjusting the cellular phenotype.
Proteoglycans are intricate macromolecules formed by a central protein and one or more covalently linked glycosaminoglycan chain. The natural actions of proteoglycans results mainly from the structurally prevalent glycosaminoglycans emanating from the protein nucleus of the molecule.
Glycosaminoglycans modulate the activity of fibroblast growth factor (FGF) signaling which is crucial in a wide range of important biological activities with differential effects in various cell types. They affect FGF signaling by interacting with both the growth factor and the FGF receptor.
Fibroblast Growth Factors are polypeptides(proteins) that bind to receptors on the cell surface, with the primary result of activating cellular proliferation and
/or differentiation. Many growth factors are quite versatile, stimulating cellular division in different cell types; while others are specific to a particular cell-type. There are at least 21 distinct members of the FGF family of growth factors.
Fibroblast growth factors work specifically on several kinds of epithelial cells like keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, some kinds of Fibroblast Growth Factor have been demonstrated to be more than growth factors: they can shield epithelial cells from negative alterations produced, for example, by radiation and oxidative stress.
The main function of fibroblasts is to maintain the structural integrity of connective tissue by continuously secreting precursors of the extracellular matrix. Fibroblasts and the glycoconjugates mentioned are critical in wound healing. The dynamic process is interactive and depends on proper regulation of fibroblasts. These structural elements comprise collagen and elastin connective tissues and glycosaminoglycans and proteoglycans. Without proper regulation of fibroblast activity, excessive scarring results and is a feature of impaired healing (keloid and hypertrophic scars). This impairment is a serious health problem that most of the time affects a person’s quality of life due to the fact that treatment costs are high and the results are often unsatisfactory.
Tissue damage stimulates fibrocytes and induces migration and proliferation of fibroblasts in multiple stages of tissue repair including wound contraction. Fibroblasts can give rise to other cells, such as bone cells, fat cells, and smooth muscle cells. All those are cells of mesodermal origin, which means a layer from which the organs and tissues of the body develop through further differentiation.
GAGs are usually found in the extracellular matrix of vertebrate and invertebrate tissues. A large number of animal species contain GAGs while mollusks are a particularly rich source of these polysaccharides. Furthermore, a structural investigation revealed that in invertebrate species GAGs often contain unusual variations of sulfate distribution and uronic acids.
A natural skin care cream that restores skin moisture and is made with secretions from snails of the species known as Helix Aspersa Muller helps heal skin conditions. The secretion is the same these little creatures use to protect and repair the collagen and elastin in their skin when damaged and is packed with GAGs. It is a substance rich with glycoconjugates that enhances the skin’s ability to produce collagen, elastin plus glycosaminoglycans and proteoglycans. These molecules are always present in the dermis and have a large water holding capacity -true moisturizing- and thus provide support and skin strength, helping skin that is about to be stretched withstand tension and compression forces without tearing. It also helps to firm the skin and avoid sagging and wrinkles.